A part from its inflammatory, infectious, degenerative, metabolic, neoplastic nature, a disease arises and evolves in relation to the individual constitution, since environmental factor, surely important, interacts with genetic factor always present, as clinical evidence shows it. As extreme example, let us consider the “traumatic” pathology: if the diseased subject does not die, of course, fracture evolves and ends in relation to patient constitution. In fact, there are notoriously identical cases, as concerns the initial severity, among them some people rapidly and completely recover, while other undergo morbidity and even mortality, due to complications, clearly in relation to efficacious tissue repair, bone synthesis, tissue heal, all events genetically directed. The primary role played by the constitution is manifest also in infectious diseases, incuding the common children diseases, viral in origin, which evolve especially, although not exclusivelly, in relation to psycho-physical situation of every individual and certainly to sensitivity to treatment, although nowadays only specific vaccines are successfull. The constitutional factor shows its primary role in degenerativeas well as metabolic diseases, in chronic inflammations, in connectivitis, and malignancies, as we demonstrated previously (1,11) (See web site http://www.semeioticabiofisica.it). There is nowadays a general agreement with the fact that “genotype” influences both the onset and the course of most commom and frequent human diseases, very often associated with environmental factors, since it is plain that “without rice-field the rice does not grow”.
To summarize, a part from its inflammatory, infectious, degenerative, metabolic, rheumatic, neoplastic nature, a disease arises and evolves in relation to the individual constitution, since environmental factor, surely determinative, must react with the genetic factor, which is always present. Biophysical Semeiotics, enlarging enormeously the borderland, really limited, of traditional, orthodox, physical semeiotics, allowed us, over the last decades, to precisely define a lot of constitutions, as we illustrated in previous papers (See Bibliography in the above-cited website). In characterising biophysical-semeiotic constitutions, we started from the hypothesis or conjecture – then revealed truh, scientifically speaking – that “altered” genome, nuclear as wel as mitochondrial, modifies both function-structure of various parenchymas and function-structure of related microvessels, thus, permitting us to enlarge and complete Tischendorf’s concept of Angiobiotopie. Finally, by means of the original physical semeiotics, which proved to be essential and precious in giving rise to Clinical Microangiology, doctor now is able to recognize at the bed-side functional-structural modifications of tissue-microvascular-units, characteristic of the diverse constitutions, starting from two first decades of individual life.
Clinical evidence demonstrates that the dyspipidaemic constitution necessarily exists: among individuals comparable as far as age, sex, social state, lifestyle, diet, a.s.o., are concerned, some are dyslipidaemic, while other are not. In addition, among children of dyslipidaemic parents only some show high cholesterol concemtretation (total Ch. and/or LDL and/or non-HDL) as well as tryglyceridies, of course, when diet, etymologically speaking, i.e. day program, is the same. Finally, among individual with identical lipidaemic concentrations values, the seriousness of well-known disorders are clearly different. Therefore, the “real” risk of dyslipidaemia, based on genetic alterations, truhly exists, as allows to state clinical evidence, beyond actual genetic investigations. In a few minutes, Biophysical Semeiotics permits doctor to recognize, at the bed-side and in “quantitative” manner, both the presence of dyslipidaemic constitution and dysplipidaemia, by a large number of methods, which obviously need a very different knowledge of this original semeiotics. As follows, in the interst of reader not jet experienced in this diagnostic method, we will illustrate two ways, easy enough to perform, certainly reliable in recognizing dyslipidaemic situations, even in intial stages, until now undiagnosed clinically.