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Preoperative Biliary Drainage

SP Kaushik, MBBS, FRCS, PhD (London), FAMS

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Pre-operative Bilary Drainage – Yes or No?

The preoperative biliary drainage in surgical obstructive jaundice patients performed by any of the following methods;

  1. PTBD (Percutaneous transhepatic biliary drainage)
  2. Endoscopic drainage
  3. Surgical drainage

The drainage is advocated with objectives of improving results of surgery, improving benefits to patient’s health and well being and to make curative resections possible. It is therefore important to analyse critically as to what extent these objectives are nearly fulfilled.

Does the preoperative biliary drainage improves results of surgery?

McPherson et al, in 1984 published results of a controlled clinical trial conducted on 70 patients. Five patients were excluded from the study as drop outs, 31 patients had surgery alone and 34 underwent PTBD. These authors found that there was increased morbidity and mortality in patients who underwent PTBD.

Lukes et al, in 1985 studied 104 patients undergoing PTBD and 33 patients who underwent no drainage. They found no significant differences in postoperative complications and mortality in the two groups.

Ballinger et al, in 1998 observed that tumour necrosis factor before and after drainage remained unchanged. No effect was therefore seen on postoperative morbidity and mortality in any of the group. Hochwald et al in 1999 found that preoperative stenting increased the incidence of contaminated bile and hence the occurrence of postoperative infective complications.

Similarly two other trials on PTBD have shown no beneficial effect of drainage on postoperative morbidity and mortality. (Hatfield 1982, Pitt 1985) On the other hand the procedure of PTBD did increase the hospital stay. Other two trials with internal drainage instead of PTBD have shown results to be equivocal. (Smith 1985, Lai 1994)

Does preoperative drainage provides benefit to patient health and well being?

For Bilirubin levels to reach to normal it takes 4 days to 3 weeks time after drainage. (Nakayama et al – 1995) No uniform or universal drop in serum levels of bilirubin has also been observed.

Endotoxemia and immunological alterations also take weeks to improve after drainage. (Greve et al 1992, Climents et al 1993, Thompson et al 1998.)

Disturbed Cell biology as indicated by altered hepatocyte morphology and functions is also seen to persist for weeks inspite of drainage. (Koyama et al 1981, Fraser et al 1989, Masayoshi 1995.)

A number of Lacunae thus exist in one’s understanding of physiological & biochemical changes after drainage in SOJ patients. Since most of these studies are animal experiments it is difficult to extrapolate results to humen. There is paucity of clinical studies. The time frames for return of normal values have not been defined clearly. Similarly time frames for ill effects of altered functions and morphology to disappear and/or to normalize are yet to be established.

Singh et al, in 1998 studied the recovery of Liver Functions after surgical decompression in Surgical Obstructive Jaundice patients. Bilirubin levels dropped to normal range only in 54% patients by 4th day. There was delayed GI excretion of radioisotope in 26% of patients and the total time taken for complete recovery of liver functions was not less than 6 weeks. No such clinical study has become available after non-surgical preoperative drainage.

Equally important aspect of preoperative biliary drainage is the possibility of procedure related complications in these patients. (RA Sastry & S Sivam, 1998)

FAMS Professor of Surgery Government Medical College,
Chandigarh Adviser,
Armed Forces Medical Services, Govt. of India.
Formerly: President, Indian Association of Surgical Gastroenterology.Prof. and Head, Department of Surgical Gastroenterology, Sanjay Gandhi P.G.I., Lucknow; Member, Governing Council, Association of Surgeons of India. Address for correspondence: House No.1108, Sec. 32B, Chandigarh-160047 Tele: 0172- 601500 Fax: 0172-647500

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